Pathogenesis of polymyalgia rheumatica

被引：28

作者：

Guggino, G. ^{[1
]}

Ferrante, A. ^{[1
]}

Macaluso, F. ^{[1
]}

Triolo, G. ^{[1
]}

Ciccia, F. ^{[1
]}

机构：

[1] Univ Palermo, Div Rheumatol, Biomed Dept Internal Med, Piazza Clin 2, I-90127 Palermo, Italy

来源：

REUMATISMO | 2018年 / 70卷 / 01期

关键词：

Polymyalgia rheumatica; Innate immunity; Adaptive immunity; Pathogenesis;

D O I：

10.4081/reumatismo.2018.1048

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with pant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance between Th17 and Treg cells. Disturbed B cell distribution and function have been also demonstrated in PMR patients suggesting a pathogenesis more complex than previously imagined. In this review we will discuss the recent findings regarding the pathogenesis of PMR.

引用

页码：10 / 17

页数：8

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