THE DUOCARMYCINS - SYNTHETIC AND MECHANISTIC STUDIES

被引：137
作者：
BOGER, DL
机构：
[1] Department of Chemistry, Scripps Research Institute, California, 10666 North Torrey Pines Road, La Jolla
来源：
ACCOUNTS OF CHEMICAL RESEARCH | 1995年 / 28卷 / 01期
关键词：
D O I：
10.1021/ar00049a004
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：20 / 29
页数：10
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[21]   CHEMICAL AND STRUCTURAL COMPARISON OF N-BOC-CBQ AND N-BOC-CBI - IDENTIFICATION AND STRUCTURAL ORIGIN OF AN UNAPPRECIATED BUT PRODUCTIVE STABILITY OF THE CC-1065 AND DUOCARMYCIN SA ALKYLATION SUBUNITS [J].
BOGER, DL ;
MESINI, P ;
TARBY, CM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (14) :6461-6462
[22]   SYNTHESIS AND EVALUATION OF ABORTED AND EXTENDED CC-1065 FUNCTIONAL ANALOGS - (+)-CPI-PDE-I1, AND (-)-CPI-PDE-I1, (+)-CPI-PDE-I1, AND (-)-CPI-CDPI1, AND (+/-)-CPI-PDE-I1, (+)-CPI-PDE-I1, AND (-)-CPI-CDPI3 - PREPARATION OF KEY PARTIAL STRUCTURES AND DEFINITION OF AN ADDITIONAL FUNCTIONAL-ROLE OF THE CC-1065 CENTRAL AND RIGHT-HAND SUBUNITS [J].
BOGER, DL ;
COLEMAN, RS ;
INVERGO, BJ ;
SAKYA, SM ;
ISHIZAKI, T ;
MUNK, SA ;
ZARRINMAYEH, H ;
KITOS, PA ;
THOMPSON, SC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (12) :4623-4632
[23]   DESIGN, SYNTHESIS, AND EVALUATION OF DNA MINOR-GROOVE BINDING-AGENTS - THE DUOCARMYCINS [J].
BOGER, DL .
PURE AND APPLIED CHEMISTRY, 1994, 66 (04) :837-844
[24]   DESIGN, SYNTHESIS, AND EVALUATION OF DNA MINOR-GROOVE BINDING-AGENTS [J].
BOGER, DL .
PURE AND APPLIED CHEMISTRY, 1993, 65 (06) :1123-1132
[25]   SYNTHESIS OF N-(PHENYLSULFONYL)-CI, N-((TERT-BUTYLOXY)CARBONYL)-CI, CI-CDPI1, AND CI-CDPI2 - CC-1065 FUNCTIONAL ANALOGS INCORPORATING THE PARENT 1,2,7,7A-TETRAHYDROCYCLOPROP[1,2-C]INDOL-4-ONE (CI) LEFT-HAND SUBUNIT [J].
BOGER, DL ;
WYSOCKI, RJ ;
ISHIZAKI, T .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (13) :5230-5240
[26]   STUDIES ON THE TOTAL SYNTHESIS OF CC-1065 - PREPARATION OF A SYNTHETIC, SIMPLIFIED 3-CARBAMOYL-1,2-DIHYDRO-3H-PYRROLO[3,2-E]INDOLE DIMER/TRIMER/TETRAMER (CDPI DIMER/TRIMER/TETRAMER) AND DEVELOPMENT OF METHODOLOGY FOR PDE-I DIMER METHYL-ESTER FORMATION [J].
BOGER, DL ;
COLEMAN, RS ;
INVERGO, BJ .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (08) :1521-1530
[27]   TOTAL SYNTHESIS AND EVALUATION OF (+/-)-N-(TERT-BUTYLOXYCARBONYL)-CBI, (+/-)-CBI-CDPI1, AND (+/-)-CBI-CDPI2 - CC-1065 FUNCTIONAL AGENTS INCORPORATING THE EQUIVALENT 1,2,9,9A-TETRAHYDROCYCLOPROP[1,2-C]BENZ[1,2-E]INDOL-4-ONE (CBI) LEFT-HAND SUBUNIT [J].
BOGER, DL ;
ISHIZAKI, T ;
WYSOCKI, RJ ;
MUNK, SA ;
KITOS, PA ;
SUNTORNWAT, O .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (16) :6461-6463
[28]   SYNTHESIS AND PRELIMINARY EVALUATION OF (+)-CBI-INDOLE2 - AN ENHANCED FUNCTIONAL ANALOG OF (+)-CC-1065 [J].
BOGER, DL ;
ISHIZAKI, T ;
SAKYA, SM ;
MUNK, SA ;
KITOS, PA ;
JIN, Q ;
BESTERMAN, JM .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (02) :115-120
[29]   (+)- AND ENT-(-)-DUOCARMYCIN SA AND (+)- AND ENT-(-)-N-BOC-DSA DNA ALKYLATION PROPERTIES - ALKYLATION SITE MODELS THAT ACCOMMODATE THE OFFSET AT-RICH ADENINE N3 ALKYLATION SELECTIVITY OF THE ENANTIOMERIC AGENTS [J].
BOGER, DL ;
JOHNSON, DS ;
YUN, WY .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (05) :1635-1656
[30]   INTRAMOLECULAR DIELS-ALDER REACTIONS OF 1,2-DIAZINES - GENERAL INDOLINE SYNTHESIS - STUDIES ON THE PREPARATION OF THE CENTRAL AND RIGHT-HAND SEGMENTS OF CC-1065 [J].
BOGER, DL ;
COLEMAN, RS .
JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (12) :2240-2245
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