SEROLOGICAL REACTIVITY AGAINST CYST AND TACHYZOITE ANTIGENS OF TOXOPLASMA-GONDII DETERMINED BY FAST-ELISA

被引：8
作者：
ZHANG, YW
FRASER, A
BALFOUR, AH
WREGHITT, TG
GRAY, JJ
SMITH, JE
机构：
[1] UNIV LEEDS, DEPT PURE & APPL BIOL, LEEDS LS2 9JT, W YORKSHIRE, ENGLAND
[2] ADDENBROOKES HOSP, CLIN MICROBIOL & PUBL HLTH LAB, CAMBRIDGE CB2 2QW, ENGLAND
来源：
JOURNAL OF CLINICAL PATHOLOGY | 1995年 / 48卷 / 10期
关键词：
FAST-ELISA; TOXOPLASMA GONDII; ANTIGEN; CYST ANTIGEN;
D O I：
10.1136/jcp.48.10.908
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Aims-To obtain quantitative data on the human serological response to Toxoplas Methods-Serum samples from 30 patients who had positive antibody titres against T gondii and from 14 who were seronegative, together with sequential serum samples from four infected individuals, were screened by FAST-ELISA. Results-Serum samples from the 30 seropositive patients showed high IgG and IgM titres against the T gondii tachyzoite antigen but very low responses to cyst antigen. This result was borne out in sequential serum samples from patients with toxoplasmosis. Conclusion-Antibody recognition of the cystic stage of T gondii is low, implying that either this stage is poorly immunogenic or that the antigen load is low.
引用
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页码：908 / 911
页数：4
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