Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?

被引：41

作者：

Akassou, Amal ^{[1
]}

Bakri, Youssef ^{[1
]}

机构：

[1] Mohammed V Univ, Fac Sci, Lab Biochem & Immunol, Ave Ibn Battouta,BP 1014, Rabat, Morocco

来源：

CLINICAL MEDICINE INSIGHTS-ARTHRITIS AND MUSCULOSKELETAL DISORDERS | 2018年 / 11卷

关键词：

HLA-B27; ankylosing spondylitis; clinical features; severity;

D O I：

10.1177/1179544117751627

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientific community. It is important to understand its etiopathogenic mechanism and its functions in these diseases. Although the diagnostic and prognostic roles of HLA-B27 in AS are still debated, there is an increasing interest for HLA-B27-based effects especially in HLA-B27(+) patients with AS. This review will focus in the examination of published reports regarding the influence of HLA-B27 status on the demographic and clinical features in AS, with specific interest to its role on AS severity.

引用

页数：6

共 61 条

[41] HLA-B27 polymorphism in patients with juvenile and adult-onset ankylosing spondylitis in Southern China [J].

Mou, Y. ;

Wu, Z. ;

Gu, J. ;

Liao, Z. ;

Lin, Z. ;

Wei, Q. ;

Huang, J. ;

Li, Q. .

TISSUE ANTIGENS, 2010, 75 (01) :56-60

[42] Clinical Features in Juvenile-Onset Ankylosing Spondylitis Patients Carrying Different B27 Subtypes [J].

Mou, Yikun ;

Zhang, Pingping ;

Li, Qiuxia ;

Lin, Zhiming ;

Liao, Zetao ;

Wei, Qiujing ;

Gu, Jieruo .

BIOMED RESEARCH INTERNATIONAL, 2015, 2015

[43] Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants [J].

Newport, Melanie ;

Sirugo, Giorgio ;

Lyons, Emily ;

Vannberg, Fredrik ;

Hill, Adrian V. S. ;

Bradbury, Linda A. ;

Farrar, Claire ;

Pointon, Jennifer J. ;

Wordsworth, Paul ;

Brown, Matthew A. ;

Franklyn, Jayne A. ;

Heward, Joanne M. ;

Simmonds, Matthew J. ;

Gough, Stephen C. L. ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Ban, Maria ;

Goris, An ;

Sawcer, Stephen J. ;

Compston, Alastair ;

Conway, David ;

Jallow, Muminatou ;

Newport, Melanie ;

Sirugo, Giorgio ;

Rockett, Kirk A. ;

Kwiatkowski, Dominic P. ;

Bumpstead, Suzannah J. ;

Chaney, Amy ;

Downes, Kate ;

Ghori, Mohammed J. R. ;

Gwilliam, Rhian ;

Hunt, Sarah E. ;

Inouye, Michael ;

Keniry, Andrew ;

King, Emma ;

McGinnis, Ralph ;

Potter, Simon ;

Ravindrarajah, Rathi ;

Whittaker, Pamela ;

Widden, Claire ;

Withers, David ;

Deloukas, Panos ;

Leung, Hin-Tak ;

Nutland, Sarah ;

Stevens, Helen E. ;

Walker, Neil M. ;

Todd, John A. ;

Easton, Doug ;

Clayton, David G. .

NATURE GENETICS, 2007, 39 (11) :1329-1337

[44] Human leucocyte antigen-B27 subtypes in Korean patients with ankylosing spondylitis: higher B*2705 in the patient group [J].

Park, Sung-Hoon ;

Kim, JiHun ;

Kim, Sang-Gyung ;

Kim, Seong-Kyu ;

Chung, Won Tae ;

Choe, Jung-Yoon .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2009, 12 (01) :34-38

[45]

Popescu C, 2014, J Med Life, V7, P78

[46] Outcomes in anterior uveitis associated with the HLA-B27 haplotype [J].

Power, WJ ;

Rodriguez, A ;

Pedroza-Seres, M ;

Foster, CS .

OPHTHALMOLOGY, 1998, 105 (09) :1646-1651

[47] Higher risk of uveitis and dactylitis and older age of onset among ankylosing spondylitis patients with HLA-B*2705 than patients with HLA-B*2704 in the Chinese population [J].

Qi, J. ;

Li, Q. ;

Lin, Z. ;

Liao, Z. ;

Wei, Q. ;

Cao, S. ;

Rong, J. ;

Hu, Z. ;

Yang, M. ;

Zhang, Y. ;

Lv, Q. ;

Huang, J. ;

Pan, Y. ;

Wu, Y. ;

Jin, O. ;

Li, T. ;

Gu, J. .

TISSUE ANTIGENS, 2013, 82 (06) :380-386

[48] Major histocompatibility genes and ankylosing spondylitis [J].

Reveille, John D. .

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2006, 20 (03) :601-609

[49] How to diagnose axial spondyloarthritis early [J].

Rudwaleit, M ;

van der Heijde, D ;

Khan, MA ;

Braun, J ;

Sieper, J .

ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 (05) :535-543

[50] HIGH ASSOCIATION OF AN HL-A ANTIGEN, W27, WITH ANKYLOSING-SPONDYLITIS [J].

SCHLOSSTEIN, L ;

TERASAKI, PI ;

BLUESTONE, R ;

PEARSON, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 1973, 288 (14) :704-706

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