Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?

被引：41

作者：

Akassou, Amal ^{[1
]}

Bakri, Youssef ^{[1
]}

机构：

[1] Mohammed V Univ, Fac Sci, Lab Biochem & Immunol, Ave Ibn Battouta,BP 1014, Rabat, Morocco

来源：

CLINICAL MEDICINE INSIGHTS-ARTHRITIS AND MUSCULOSKELETAL DISORDERS | 2018年 / 11卷

关键词：

HLA-B27; ankylosing spondylitis; clinical features; severity;

D O I：

10.1177/1179544117751627

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the intriguing models that could exist between a molecule and human disease in medicine. Although it was reported in 1973, its contribution to AS and related spondyloarthritis continues to be a major challenge for scientific community. It is important to understand its etiopathogenic mechanism and its functions in these diseases. Although the diagnostic and prognostic roles of HLA-B27 in AS are still debated, there is an increasing interest for HLA-B27-based effects especially in HLA-B27(+) patients with AS. This review will focus in the examination of published reports regarding the influence of HLA-B27 status on the demographic and clinical features in AS, with specific interest to its role on AS severity.

引用

页数：6

共 61 条

[1] Prevalence of HLA-B27 in Moroccan healthy subjects and patients with ankylosing spondylitis and mapping construction of several factors influencing AS diagnosis by using multiple correspondence analysis [J].

Akassou, Amal ;

Yacoubi, Hanae ;

Jamil, Afaf ;

Dakka, Nadia ;

Amzazi, Saaid ;

Sadki, Khalid ;

Niamane, Redouane ;

Elhassani, Selma ;

Bakri, Youssef .

RHEUMATOLOGY INTERNATIONAL, 2015, 35 (11) :1889-1894

[2] GUILT BY ASSOCIATION - HLA-B27 AND ANKYLOSING-SPONDYLITIS [J].

BENJAMIN, R ;

PARHAM, P .

IMMUNOLOGY TODAY, 1990, 11 (04) :137-142

[3] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :506-512

[4] Genetic variability, molecular evolution, and geographic diversity of HLA-B27 [J].

Blanco-Gelaz, MA ;

López-Vázquez, A ;

García-Fernández, S ;

Martínez-Borra, J ;

González, S ;

López-Larrea, C .

HUMAN IMMUNOLOGY, 2001, 62 (09) :1042-1050

[5] HLA-B27 [J].

Bowness, Paul .

ANNUAL REVIEW OF IMMUNOLOGY VOL 33, 2015, 33 :29-48

[6] Th17 Cells Expressing KIR3DL2+ and Responsive to HLA-B27 Homodimers Are Increased in Ankylosing Spondylitis [J].

Bowness, Paul ;

Ridley, Anna ;

Shaw, Jacqueline ;

Chan, Antoni T. ;

Wong-Baeza, Isabel ;

Fleming, Myles ;

Cummings, Fraser ;

McMichael, Andrew ;

Kollnberger, Simon .

JOURNAL OF IMMUNOLOGY, 2011, 186 (04) :2672-2680

[7]

Braun J, 1998, ARTHRITIS RHEUM-US, V41, P58, DOI 10.1002/1529-0131(199801)41:1<58::AID-ART8>3.3.CO

[8]

2-7

[9]

BREWERTON DA, 1973, LANCET, V1, P904

[10] Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis [J].

Brown, MA ;

Laval, SH ;

Brophy, S ;

Calin, A .

ANNALS OF THE RHEUMATIC DISEASES, 2000, 59 (11) :883-886

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