RAPID DISRUPTION OF EPITHELIAL BARRIER FUNCTION BY SALMONELLA-TYPHIMURIUM IS ASSOCIATED WITH STRUCTURAL MODIFICATION OF INTERCELLULAR-JUNCTIONS

被引：82
作者：
JEPSON, MA
COLLARESBUZATO, CB
CLARK, MA
HIRST, BH
SIMMONS, NL
机构：
来源：
INFECTION AND IMMUNITY | 1995年 / 63卷 / 01期
基金：
英国惠康基金;
关键词：
D O I：
10.1128/IAI.63.1.356-359.1995
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Short term infection of MDCK II monolayers with Salmonella typhimurium SL1344 caused a progressive decrease in transepithelial electrical resistance concomitant with decreased cation permselectivity and increased paracellular inulin flux. Cytochemical staining of F-actin, E-cadherin, and ZO-1 revealed the concentration of each junctional protein in invaded cells as a result of contraction at their apical poles and resultant distortion of adjacent uninvaded cells.
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页码：356 / 359
页数：4
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