HERITABILITY OF AEROBIC POWER AND ANAEROBIC ENERGY GENERATION DURING EXERCISE

被引:106
作者
FAGARD, R [1 ]
BIELEN, E [1 ]
AMERY, A [1 ]
机构
[1] CATHOLIC UNIV LEUVEN,DEPT PATHOPHYSIOL,HYPERTENS & CARDIOVASC REHABIL UNIT,B-3000 LOUVAIN,BELGIUM
关键词
OXYGEN UPTAKE; RESPIRATORY GAS ANALYSIS; TWINS;
D O I
10.1152/jappl.1991.70.1.357
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Twenty-nine pairs of monozygotic twins and 19 pairs of dizygotic twins, all male, ages 18-31 yr, performed a graded uninterrupted exercise test on the bicycle ergometer to exhaustion. By use of path analysis, the genetic variance of measured peak O2 uptake was estimated at 77% (P < 0.001), at 71% (P < 0.001) after adjustment for weight and skinfold thickness, and at 66% (P < 0.001) after additional adjustment for weekly hours of sports participation. O2 uptake at a heart rate of 150 beats/min, a submaximal estimate of exercise capacity, showed less genetic variance, i.e., 61% (P < 0.001) before and 50% (P < 0.001) after weight adjustment and only 16% (NS) after correction for life-style factors. Similarly, the heritability of peak O2 uptake, when estimated from submaximal data, was 68% (P < 0.001), 40% (P = 0.05), and 26% (NS), respectively. Mechanical efficiency had no significant genetic component. O2 uptake at the respiratory exchange ratio of 0.95 and the slope of the curvilinear relationship between CO2 output and O2 uptake, used to assess the anaerobic energy generation during progressive exercise, showed significant (P < 0.001) genetic variance before (72 and 74%) and after adjustment for weight (67 and 69%) and sports participation (63 and 57%). The heritability of peak aerobic power remained significant (58%; P < 0.001) after adjustment for these expressions of anaerobic energy generation. In conclusion the genetic variance of measured peak O2 uptake is significant and persists after adjustment for anthropometric characteristics, lifestyle factors, anaerobic energy generation, and mechanical efficiency. Estimated peak O2 uptake and O2 uptake at heart rate of 150 beats/min show a lower genetic variability.
引用
收藏
页码:357 / 362
页数:6
相关论文
共 23 条
[1]   HERITABILITY OF CARDIAC SIZE - AN ECHOCARDIOGRAPHIC AND ELECTROCARDIOGRAPHIC STUDY OF MONOZYGOTIC AND DIZYGOTIC TWINS [J].
ADAMS, TD ;
YANOWITZ, FG ;
FISHER, AG ;
RIDGES, JD ;
NELSON, AG ;
HAGAN, AD ;
WILLIAMS, RR ;
HUNT, SC .
CIRCULATION, 1985, 71 (01) :39-44
[2]   SUBMAXIMAL POWER OUTPUT IN ADOPTED AND BIOLOGICAL SIBLINGS [J].
BOUCHARD, C ;
LORTIE, G ;
SIMONEAU, JA ;
LEBLANC, C ;
THERIAULT, G ;
TREMBLAY, A .
ANNALS OF HUMAN BIOLOGY, 1984, 11 (04) :303-309
[3]  
BOUCHARD C, 1986, MED SCI SPORT EXER, V18, P639
[4]   TESTING TWIN MEANS AND ESTIMATING GENETIC VARIANCE - BASIC METHODOLOGY FOR THE ANALYSIS OF QUANTITATIVE TWIN DATA [J].
CHRISTIAN, JC .
ACTA GENETICAE MEDICAE ET GEMELLOLOGIAE, 1979, 28 (01) :35-40
[5]  
CLARK PJ, 1956, AM J HUM GENET, V7, P49
[6]   BODY FAT ASSESSED FROM TOTAL-BODY DENSITY AND ITS ESTIMATION FROM SKINFOLD THICKNESS - MEASUREMENTS ON 481 MEN AND WOMEN AGED FROM 16 TO 72 YEARS [J].
DURNIN, JVGA ;
WOMERSLEY, J .
BRITISH JOURNAL OF NUTRITION, 1974, 32 (01) :77-97
[7]   PHYSICAL CAPACITY IN TWINS [J].
ENGSTROM, LM ;
FISCHBEIN, S .
ACTA GENETICAE MEDICAE ET GEMELLOLOGIAE, 1977, 26 (02) :159-165
[8]   MAXIMUM OXYGEN-UPTAKE AND CARDIAC SIZE AND FUNCTION IN TWINS [J].
FAGARD, R ;
VANDENBROEKE, C ;
BIELEN, E ;
AMERY, A .
AMERICAN JOURNAL OF CARDIOLOGY, 1987, 60 (16) :1362-1367
[9]  
FAGARD R, 1984, BRIT HEART J, V52, P124
[10]   TESTING STRUCTURAL EQUATION MODELS FOR TWIN DATA USING LISREL [J].
HEATH, AC ;
NEALE, MC ;
HEWITT, JK ;
EAVES, LJ ;
FULKER, DW .
BEHAVIOR GENETICS, 1989, 19 (01) :9-35