REGULATORY CHANGES IN PRESYNAPTIC CHOLINERGIC FUNCTION ASSESSED IN RAPID AUTOPSY MATERIAL FROM PATIENTS WITH ALZHEIMER-DISEASE - IMPLICATIONS FOR ETIOLOGY AND THERAPY

被引：82

作者：

SLOTKIN, TA

SEIDLER, FJ

CRAIN, BJ

BELL, JM

BISSETTE, G

NEMEROFF, CB

机构：

[1] DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710

[2] DUKE UNIV,MED CTR,DEPT PSYCHIAT,DURHAM,NC 27710

[3] DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DURHAM,NC 27710

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 07期

关键词：

D O I：

10.1073/pnas.87.7.2452

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Brain regions from patients with or without Alzheimer disease (AD) were obtained within 2 hr of death and examined for indices of presynaptic cholinergic function. Consistent with loss of cholinergic projections, cerebral cortical areas involved in AD exhibited decreased choline acetyltransferase (acetyl-CoA:choline 0-acetyltransferase, EC 2.3.1.6) activity. However, remaining nerve terminals in these regions displayed marked up-regulation of synaptosomal high affinity [3H]choline uptake, a result indicative of relative cholinergic hyperactivity. As choline uptake is also rate-limiting in acetylcholine biosynthesis, these findings have implications for both therapy and identification of causes contributing to neuronal death in AD.

引用

页码：2452 / 2455

页数：4

共 30 条

[1]

ADAMS JH, 1984, GREENFIELDS NEUROPAT

[2]

BIRKMAYER W, 1983, PARKINSONS DISEASE B

[3] CORTICOTROPIN-RELEASING FACTOR-LIKE IMMUNOREACTIVITY IN SENILE DEMENTIA OF THE ALZHEIMER TYPE - REDUCED CORTICAL AND STRIATAL CONCENTRATIONS [J].