INFLUENCE OF LEFT-VENTRICULAR FUNCTION ON OUTCOME OF PATIENTS TREATED WITH IMPLANTABLE DEFIBRILLATORS

被引:91
作者
KIM, SG
FISHER, JD
CHOUE, CW
GROSS, J
ROTH, J
FERRICK, KJ
BRODMAN, R
FURMAN, S
机构
[1] MONTEFIORE MED CTR,DEPT CARDIOTHORAC SURG,BRONX,NY 10467
[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,BRONX,NY 10461
关键词
SUDDEN DEATH; IMPLANTABLE DEFIBRILLATORS; VENTRICULAR FIBRILLATION;
D O I
10.1161/01.CIR.85.4.1304
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. The outcomes of patients treated with implantable defibrillators were compared between patients with left ventricular ejection fraction greater-than-or-equal-to 30% and < 30%. Methods and Results. Of 68 consecutive patients treated with implantable defibrillators, 40 patients (group 1) had left ventricular ejection fraction greater-than-or-equal-to 30%, and 28 patients (group 2) had left ventricular ejection fraction < 30%. Sudden death, surgical mortality, nonsudden arrhythmia-related death (death within 24 hours after an arrhythmic event despite initial termination of the arrhythmia by the implantable defibrillator), total arrhythmia-related death (including sudden death, surgical death, and nonsudden arrhythmia-related death), and total cardiac death were compared between the two groups. Surgical mortality was 4.4% (0% in group 1, 11% in group 2). During the follow-up of 31 +/- 27 months, actuarial survival rates free of events were 97%, 97%, and 97% in group 1 and 96%, 91%, and 82% in group 2 at 12, 24, and 36 months, respectively, for sudden death (p = NS); 97%, 97%, and 97% in group 1 and 85%, 81%, and 72% in group 2 at 12, 24, and 36 months, respectively, for sudden death and surgical mortality (p < 0.05); 97%, 97%, and 97% in group 1 and 82%, 78%, and 70% in group 2 at 12, 24, and 36 months, respectively, for total arrhythmia-related death (p < 0.05); and 95%, 95%, and 95% in group 1 and 82%, 69%, and 57% in group 2 at 12, 24, and 36 months, respectively, for total cardiac death (p < 0.05). Four (57%) of seven nonsudden cardiac deaths during the initial 36-month follow-up period were causally related to arrhythmia (three surgical deaths and one arrhythmia-related nonsudden death). Conclusions. The outcome of patients treated with implantable defibrillators is strongly influenced by the degree of left ventricular dysfunction. In group 1 patients, surgical mortality, sudden death, and total cardiac death are rare. In group 2, sudden death rate may not be markedly different from that of group 1 patients. However, the risk of therapy (surgical mortality) is high. Many nonsudden cardiac deaths are causally related to arrhythmia (surgical mortality or nonsudden arrhythmia-related death). Therefore, the survival rate free of total arrhythmia-related death is significantly lower in group 2 (70% versus 97% in group 1 at 3 years). Further studies are needed to determine the roles of defibrillator therapy and other therapies in various clinical settings.
引用
收藏
页码:1304 / 1310
页数:7
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