Genetic issues in pediatric cardiomyopathy: Future research directions

被引：1

作者：

Chung, Wendy ^{[1
]}

Towbin, Jeffrey ^{[2
]}

机构：

[1] Columbia Univ, 1150 St. Nicholas Ave,Room 620, New York, NY 10032 USA

[2] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA

来源：

PROGRESS IN PEDIATRIC CARDIOLOGY | 2011年 / 32卷 / 01期

关键词：

Pediatric cardiomyopathy; Cardiac disease; Genetics; Genetic testing;

D O I：

10.1016/j.ppedcard.2011.06.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pediatric cardiomyopathies are extremely heterogeneous in etiology and are thus associated with variability in prognosis and response to therapy. With increasing availability of clinical diagnostic tools and research methods to molecularly characterize genetic forms of cardiomyopathy and identify viral pathogens in myocarditis, we have the opportunity to define pediatric cardiomyopathies by molecular subtype and characterize the natural history of each subtype. By understanding the natural histories of the subtypes of pediatric cardiomyopathies, we can develop biomarkers for early stages of diseases and disease progression, and lay the foundations necessary for future clinical trials for treatment and primary prevention. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：3 / 4

页数：2

共 2 条

[1] Novel gene discovery in pediatric cardiomyopathy [J].

Chung, Wendy K. .

PROGRESS IN PEDIATRIC CARDIOLOGY, 2011, 31 (02) :89-91

[2] Compound and Digenic Heterozygosity Contributes to Arrhythmogenic Right Ventricular Cardiomyopathy [J].

Xu, Tianhong ;

Yang, Zhao ;

Vatta, Matteo ;

Rampazzo, Alessandra ;

Beffagna, Giorgia ;

Pillichou, Kalliopi ;

Scherer, Steven E. ;

Saffitz, Jeffrey ;

Kravitz, Joshua ;

Zareba, Wojciech ;

Danieli, Gian Antonio ;

Lorenzon, Alessandra ;

Nava, Andrea ;

Bauce, Barbara ;

Thiene, Gaetano ;

Basso, Cristina ;

Calkins, Hugh ;

Gear, Kathy ;

Marcus, Frank ;

Towbin, Jeffrey A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (06) :587-597

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