MOLECULAR-CLONING OF A WIDELY EXPRESSED HUMAN HOMOLOG FOR THE DROSOPHILA TRP GENE

被引：282
作者：
ZHU, X
CHU, PB
PEYTON, M
BIRNBAUMER, L
机构：
来源：
FEBS LETTERS | 1995年 / 373卷 / 03期
关键词：
TRANSIENT RECEPTOR POTENTIAL; CALCIUM INFLUX CHANNEL; CA2+ SIGNALING;
D O I：
10.1016/0014-5793(95)01038-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Drosophila transient receptor potential (trp) gene and its homologue, trpl, have been suggested to mediate calcium entry during the insect's phototransduction process. We isolated a human cDNA, human trp-1 (Htrp-1), encoding a polypeptide of 793 amino acids that is 37% identical (62% similar) to Drosophila trp and trpl, Northern analysis showed that the Htrp-1 transcript is approximately 5.5 kb and expressed in most human tissues, with higher amounts in ovary, testis, heart, and brain, Isolation of Htrp-1 suggests that a tip-type protein is present in mammals and should provide a useful tool in studying calcium-depletion induced calcium influx processes.
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收藏
页码：193 / 198
页数：6
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