DIFFERENTIAL-EFFECTS OF APOMORPHINE ON PREPULSE INHIBITION OF ACOUSTIC STARTLE REFLEX IN 2 RAT STRAINS

被引：85
|
作者：
RIGDON, GC
机构：
[1] Pharmacology Division, Burroughs Wellcome Co., Research Triangle Park, 27709, NC
来源：
PSYCHOPHARMACOLOGY | 1990年 / 102卷 / 03期
关键词：
Apomorphine; CD strain; Prepulse inhibition; Startle reflex; Wistar strain;
D O I：
10.1007/BF02244115
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Apomorphine disruption of prepulse inhibition (PPI) has been proposed as an animal model of sensorimotor gating deficits exhibited by schizophrenics. The effects of apomorphine on PPI of the acoustic startle reflex in male rats of Wistar and CD (Sprague-Dawley derived) strains were compared under identical test conditions. In Wistar rats, subcutaneous administration of 0.25-1.0 mg/kg apomorphine blocked PPI without affecting startle amplitude. In CD rats, apomorphine (0.3-3.0 mg/kg, SC) had no effect on PPI, but increased startle amplitude. Therefore, choice of rat strain is an important factor in the design of experiments studying apomorphine effects on PPI. © 1990 Springer-Verlag.
引用
收藏
页码：419 / 421
页数：3
相关论文
共 50 条
  • [21] Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex
    Jones, CK
    Shannon, HE
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2000, 294 (03): : 1017 - 1023
  • [22] A computational model for the modulation of the prepulse inhibition of the acoustic startle reflex
    David Fernando Ramirez-Moreno
    Terrence Joseph Sejnowski
    Biological Cybernetics, 2012, 106 : 169 - 176
  • [23] Prepulse inhibition and habituation of the acoustic startle blink reflex in schizophrenia
    Takahashi, H.
    Hashimoto, R.
    Iwase, M.
    Ishii, R.
    Ohi, K.
    Iike, N.
    Kurimoto, R.
    Ikezawa, K.
    Azechi, M.
    Takeda, M.
    PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2008, 62 (01) : S7 - S7
  • [24] Prepulse Inhibition of the Acoustic Startle Reflex in High Functioning Autism
    Kohl, Sina
    Wolters, Carolin
    Gruendler, Theo O. J.
    Vogeley, Kai
    Klosterkoetter, Joachim
    Kuhn, Jens
    PLOS ONE, 2014, 9 (03):
  • [25] Erratum: Noise benefit in prepulse inhibition of the acoustic startle reflex
    Erik Pålsson
    Göran Söderlund
    Daniel Klamer
    Filip Bergquist
    Psychopharmacology, 2011, 214 : 977 - 977
  • [26] Trait emotionality correlates with prepulse inhibition of the acoustic startle reflex
    Corr, PJ
    Kumari, V
    SCHIZOPHRENIA RESEARCH, 2002, 53 (03) : 215 - 215
  • [27] A computational model for the modulation of the prepulse inhibition of the acoustic startle reflex
    Fernando Ramirez-Moreno, David
    Sejnowski, Terrence Joseph
    BIOLOGICAL CYBERNETICS, 2012, 106 (03) : 169 - 176
  • [28] Effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in two rat strains
    Lisa H. Conti
    Jennifer D. Murry
    Mark A. Ruiz
    Morton P. Printz
    Psychopharmacology, 2002, 161 : 296 - 303
  • [29] Effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in two rat strains
    Conti, LH
    Murry, JD
    Ruiz, MA
    Printz, MP
    PSYCHOPHARMACOLOGY, 2002, 161 (03) : 296 - 303
  • [30] Effects of microinjections of MK-801 and NMDA into the inferior colliculus on prepulse inhibition of the acoustic startle reflex in rat
    Barbosa Da Silva, R. C.
    Labbate, G.
    Zangrando, J.
    Medeiros, P.
    Thomas-Melo, L.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2012, 15 : 111 - 111
12345