MAPPING OF THE GENE FOR THE MEL(1A)-MELATONIN RECEPTOR TO HUMAN-CHROMOSOME-4 (MTNR1A) AND MOUSE CHROMOSOME-8 (MTNR1A)

被引：82
作者：
SLAUGENHAUPT, SA
ROCA, AL
LIEBERT, CB
ALTHERR, MR
GUSELLA, JF
REPPERT, SM
机构：
[1] MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET UNIT,BOSTON,MA 02114
[2] MASSACHUSETTS GEN HOSP,DEV CHRONOBIOL LAB,BOSTON,MA 02114
[3] HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115
[4] HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115
[5] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115
[6] HARVARD UNIV,SCH MED,PROGRAM NEUROSCI,BOSTON,MA 02115
[7] LOS ALAMOS NATL LAB,GENOM & STRUCT BIOL GRP,LOS ALAMOS,NM 87545
来源：
GENOMICS | 1995年 / 27卷 / 02期
关键词：
D O I：
10.1006/geno.1995.1056
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The pineal hormone melatonin elicits potent circadian and reproductive effects in mammals. We report the chromosomal location of the gene for the Mel(1a)-melatonin receptor that likely mediates these circadian and reproductive actions, PCR analysis of human-rodent somatic cell hybrids showed that the receptor gene (MTNR1A) maps to human chromosome 4q35.1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders. (C) 1995 Academic Press, Inc.
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页码：355 / 357
页数：3
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