AMPHETAMINE AND HALOPERIDOL MODULATE PREPROTACHYKININ-A MESSENGER-RNA EXPRESSION IN RAT NUCLEUS-ACCUMBENS AND CAUDATE-PUTAMEN

被引：23
作者：
LINDEFORS, N
机构：
[1] Department of Pharmacology, Karolinska Institutet, Stockholm
来源：
MOLECULAR BRAIN RESEARCH | 1992年 / 13卷 / 1-2期
关键词：
NUCLEUS ACCUMBENS; AMPHETAMINE; CAUDATE-PUTAMEN; MESSENGER RNA; PREPROTACHYKININ-A;
D O I：
10.1016/0169-328X(92)90055-G
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In situ hybridization was used to measure the effect of repeated amphetamine (1.5 mg/kg) and haloperidol (0.5 mg/kg) treatment for 7 days on the expression of preprotachykinin A (PPT-A) mRNA in rat nucleus accumbens (Acb) and caudate-putamen (CPu). Amphetamine elevated the level of PPT-A mRNA in Acb, but not in CPu. Haloperidol decreased the levels in Acb shell and CPu, but not in Acb core. Haloperidol injected together with amphetamine, prevented the amphetamine-induced increase in PPT-A mRNA expression in both Acb core and shell.
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页码：151 / 154
页数：4
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