Iodinated silica/porphyrin hybrid nanoparticles for X-ray computed tomography/fluorescence dual-modal imaging of tumors

被引：10
作者：
Hayashi, Koichiro [1 ,2 ]
Wataru, Sakamoto [1 ]
Yogo, Toshinobu [1 ]
机构：
[1] Nagoya Univ, EcoTopia Sci Inst, Div Green Mat, Chikusa Ku, Nagoya, Aichi 4648603, Japan
[2] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Anat & Cell Biol, Tokushima 7708503, Japan
来源：
JOURNAL OF ASIAN CERAMIC SOCIETIES | 2014年 / 2卷 / 04期
关键词：
Silica; Hybrid; Nanoparticles; In vivo imaging;
D O I：
10.1016/j.jascer.2014.09.003
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Silica nanoparticles containing covalently linked iodine and a near-infrared (NIR) fluorescence dye, namely porphyrin, have been synthesized through a one-pot solgel reaction. These particles are called iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs). The ISP HNPs have both high X-ray absorption coefficient and NIR fluorescence. The ISP HNPs modified with folic acid (FA) and polyethylene glycol (PEG), denoted as FA-PEG-ISP HNPs, enabled the successful visualization of tumors in mice by both X-ray computed tomography (CT) and fluorescence imaging (FI). Thus, the FA-PEG-ISP HNPs are useful as contrast agents or probes for CT/FI dual-modal imaging. (C) 2014 The Ceramic Society of Japan and the Korean Ceramic Society. Production and hosting by Elsevier B.V. All rights reserved.
引用
收藏
页码：429 / 434
页数：6
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