A QUANTITATIVE STUDY OF THE EFFECTS OF TRIBRISSEN ON CANINE TEAR PRODUCTION

被引：35
作者：
BERGER, SL
SCAGLIOTTI, RH
LUND, EM
机构：
[1] SACRAMENTO ANIM MED GRP,CARMICHAEL,CA 95608
[2] UNIV MINNESOTA,VET HOSP,COLL VET MED,DEPT SMALL ANIM CLIN SCI,ST PAUL,MN 55108
来源：
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION | 1995年 / 31卷 / 03期
关键词：
D O I：
10.5326/15473317-31-3-236
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The effect of trimethoprim-sulfadiazinea on Schirmer tear test (STT) values was studied in a population of dogs treated with the drug for a variety of medical and postsurgical conditions. The objectives of the study were to determine the incidence of keratoconjunctivitis sicca (KCS) secondary to trimethoprim-sulfadiazine therapy; to determine if such incidence was related to dose, duration, or both; and to identify any other factors that increased patient risk. The package insert accompanying Tribrissen states that ''Dogs can tolerate up to ten times the recommended therapeutic dose without exhibiting ill effects.'' The results of this study indicated a 15.2% (5/33) incidence of KCS in the population of treated dogs.
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页码：236 / 241
页数：6
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