FATAL ENCEPHALITIS DUE TO VARIANT-B HUMAN HERPESVIRUS-6 INFECTION IN A BONE MARROW-TRANSPLANT RECIPIENT

被引：291
作者：
DROBYSKI, WR
KNOX, KK
MAJEWSKI, D
CARRIGAN, DR
机构：
[1] MED COLL WISCONSIN,DEPT MED,MILWAUKEE,WI 53226
[2] MED COLL WISCONSIN,DEPT PATHOL,MILWAUKEE,WI 53226
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 1994年 / 330卷 / 19期
关键词：
D O I：
10.1056/NEJM199405123301905
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human herpesvirus-6 (HHV-6) is the causative agent of exanthem subitum1 and febrile illnesses2 in children. More recently, HHV-6 has been shown to infect the recipients of bone marrow transplants and has been implicated in interstitial pneumonitis3,4 and bone marrow suppression5 after transplantation. The pathogenicity of HHV-6, however, has yet to be fully delineated in either immunocompetent or immunocompromised hosts. In some children with exanthem subitum, seizures, encephalopathy, and the detection of HHV-6 DNA in cerebrospinal fluid have provided circumstantial evidence that HHV-6 can infect the central nervous system6,7. Nevertheless, these studies have failed to document the direct. © 1994, Massachusetts Medical Society. All rights reserved.
引用
收藏
页码：1356 / 1360
页数：5
相关论文
共 16 条
[1]   FATAL ENCEPHALITIS ENCEPHALOPATHY IN PRIMARY HUMAN HERPESVIRUS-6 INFECTION [J].
ASANO, Y ;
YOSHIKAWA, T ;
KAJITA, Y ;
OGURA, R ;
SUGA, S ;
YAZAKI, T ;
NAKASHIMA, T ;
YAMADA, A ;
KURATA, T .
ARCHIVES OF DISEASE IN CHILDHOOD, 1992, 67 (12) :1484-1485
[2]   SUCCESSFUL ALLOGENEIC TRANSPLANTATION OF T-CELL DEPLETED BONE-MARROW FROM CLOSELY HLA-MATCHED UNRELATED DONORS [J].
ASH, RC ;
CASPER, JT ;
CHITAMBAR, CR ;
HANSEN, R ;
BUNIN, N ;
TRUITT, RL ;
LAWTON, C ;
MURRAY, K ;
HUNTER, J ;
BAXTERLOWE, LA ;
GOTTSCHALL, JL ;
OLDHAM, K ;
ANDERSON, T ;
CAMITTA, B ;
MENITOVE, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (08) :485-494
[3]   INTERSTITIAL PNEUMONITIS ASSOCIATED WITH HUMAN HERPESVIRUS-6 INFECTION AFTER MARROW TRANSPLANTATION [J].
CARRIGAN, DR ;
DROBYSKI, WR ;
RUSSLER, SK ;
TAPPER, MA ;
KNOX, KK ;
ASH, RC .
LANCET, 1991, 338 (8760) :147-149
[4]   HUMAN HERPESVIRUS-6 IN LUNG-TISSUE FROM PATIENTS WITH PNEUMONITIS AFTER BONE-MARROW TRANSPLANTATION [J].
CONE, RW ;
HACKMAN, RC ;
HUANG, MLW ;
BOWDEN, RA ;
MEYERS, JD ;
METCALF, M ;
ZEH, J ;
ASHLEY, R ;
COREY, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (03) :156-161
[5]   HUMAN HERPESVIRUS-6 (HHV-6) VARIANT-B ACCOUNTS FOR THE MAJORITY OF SYMPTOMATIC PRIMARY HHV-6 INFECTIONS IN A POPULATION OF UNITED-STATES INFANTS [J].
DEWHURST, S ;
MCINTYRE, K ;
SCHNABEL, K ;
HALL, CB .
JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (02) :416-418
[6]   PREVALENCE OF HUMAN HERPESVIRUS-6 VARIANT-A AND VARIANT-B INFECTIONS IN BONE-MARROW TRANSPLANT RECIPIENTS AS DETERMINED BY POLYMERASE CHAIN-REACTION AND SEQUENCE-SPECIFIC OLIGONUCLEOTIDE PROBE HYBRIDIZATION [J].
DROBYSKI, WR ;
EBERLE, M ;
MAJEWSKI, D ;
BAXTERLOWE, LA .
JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (06) :1515-1520
[7]   HUMAN HERPESVIRUS-6 (HHV-6) INFECTION IN ALLOGENEIC BONE-MARROW TRANSPLANT RECIPIENTS - EVIDENCE OF A MARROW-SUPPRESSIVE ROLE FOR HHV-6 INVIVO [J].
DROBYSKI, WR ;
DUNNE, WM ;
BURD, EM ;
KNOX, KK ;
ASH, RC ;
HOROWITZ, MM ;
FLOMENBERG, N ;
CARRIGAN, DR .
JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (03) :735-739
[8]   EARLY LOSS OF ASTROCYTES IN HERPES-SIMPLEX VIRUS-INDUCED CENTRAL-NERVOUS-SYSTEM DEMYELINATION [J].
ITOYAMA, Y ;
SEKIZAWA, T ;
OPENSHAW, H ;
KOGURE, K ;
GOTO, I .
ANNALS OF NEUROLOGY, 1991, 29 (03) :285-292
[9]   SEROEPIDEMIOLOGY OF HUMAN HERPESVIRUS-6 INFECTION IN NORMAL-CHILDREN AND ADULTS [J].
OKUNO, T ;
TAKAHASHI, K ;
BALACHANDRA, K ;
SHIRAKI, K ;
YAMANISHI, K ;
TAKAHASHI, M ;
BABA, K .
JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (04) :651-653
[10]   A STRONGLY IMMUNOREACTIVE VIRION PROTEIN OF HUMAN HERPESVIRUS-6 VARIANT B-STRAIN Z29 - IDENTIFICATION AND CHARACTERIZATION OF THE GENE AND MAPPING OF A VARIANT-SPECIFIC MONOCLONAL-ANTIBODY REACTIVE EPITOPE [J].
PELLETT, PE ;
SANCHEZMARTINEZ, D ;
DOMINGUEZ, G ;
BLACK, JB ;
ANTON, E ;
GREENAMOYER, C ;
DAMBAUGH, TR .
VIROLOGY, 1993, 195 (02) :521-531
12