A ROLE FOR A PRE-T-CELL RECEPTOR IN T-CELL DEVELOPMENT

被引：110
作者：
GROETTRUP, M
VONBOEHMER, H
机构：
[1] Basel Institute for Immunology, 4005 Basel
来源：
IMMUNOLOGY TODAY | 1993年 / 14卷 / 12期
关键词：
D O I：
10.1016/0167-5699(93)90201-U
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Expression of a productive T-cell receptor (TCR) beta gene has profound consequences for T-cell development, preceding an increase in thymocyte number, appearance of CD4 and CD8 coreceptors and suppression of further TCRbeta-gene rearrangement. Here Marcus Groettrup and Harald von Boehmer discuss the data obtained in various experimental models and describe a novel signal transducing receptor complex on pre-T cells, which may regulate the TCRbeta-induced developmental changes.
引用
收藏
页码：610 / 614
页数：5
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