EPITHELIAL FACTORS - MODULATION OF THE AIRWAY SMOOTH-MUSCLE TONE

被引：15
|
作者：
BERTRAND, C
TSCHIRHART, E
机构：
[1] CTR RECH PUBL SANTE,L-1150 LUXEMBOURG,LUXEMBOURG
[2] UNIV LOUIS PASTEUR,NEUROIMMUNOPHARMACOL PULM LAB,F-67401 ILLKIRCH GRAFFENS,FRANCE
来源：
FUNDAMENTAL & CLINICAL PHARMACOLOGY | 1993年 / 7卷 / 06期
关键词：
AIRWAY EPITHELIUM; RELAXING FACTORS; CONTRACTING FACTORS; METABOLISM; ARACHIDONIC ACID METABOLITE; CALCITONIN-GENE RELATED PEPTIDE;
D O I：
10.1111/j.1472-8206.1993.tb00240.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The airway epithelium is composed of a heterogeneous population of cells. This epithelial layer is not only a physical barrier but also a target responding to a variety of inflammatory mediators. These cells can respond by releasing contracting and relaxing factors to modulate airway responsiveness. They can also metabolize some of the inflammatory mediators. Epithelial damage is a consistent feature of some respiratory conditions, but whether or not such damage contributes to airway disease is for the moment unknown. This review summarizes the literature on the known and proposed roles of the epithelium in the modulation of the airway smooth muscle tone.
引用
收藏
页码：261 / 273
页数：13
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