AN EFFICIENT SYNTHESIS OF 4-HETEROFUNCTION-SUBSTITUTED 3-(1-HYDROXY)ETHYLAZETIDIN-2-ONES FROM 3-(1-HYDROXY)ETHYL-4-PHENYLSULFINYLAZETIDIN-2-ONE BY REACTION WITH SILYLATED HETERONUCLEOPHILES

被引：0

作者：

KITA, Y

SHIBATA, N

YOSHIDA, N

TOHJO, T

机构：

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 07期

关键词：

4-SULFINYLAZETIDIN-2-ONE; SILYLATED HETERONUCLEOPHILE; 3-(1-HYDROXY)ETHYLAZETIDIN-2-ONE; SUBSTITUTION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-(1-tert-Butyldimethylsiloxy)ethyl-4-sulfinylazetidin-2-one was reacted with silylated N-, S-, O-, and P-nucleophiles in the presence of a catalytic amount of ZnI2 to give the corresponding trans-4-heterofunction-substituted azetidin-2-ones in high yeilds.

引用

页码：1733 / 1736

页数：4

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