A SIMPLE ASYMMETRIC-SYNTHESIS OF 2-SUBSTITUTED PYRROLIDINES FROM 3-ACYLPROPIONIC ACIDS

被引：85
作者：
MEYERS, AI
BURGESS, LE
机构：
[1] Department of Chemistry, Colorado State University, Fort Collins
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 07期
关键词：
D O I：
10.1021/jo00007a011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The title compounds have been prepared from 3-acylpropionic acids 2 and (-)-R-phenylglycinol in a three-step sequence in > 98% enantiomeric excess. The R group in 2 ultimately becomes the 2-substituent in the chiral pyrrolidine.
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页码：2294 / 2296
页数：3
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