MECHANISM AND EVOLUTION OF THE UNCOUPLING PROTEIN OF BROWN ADIPOSE-TISSUE

被引：249
作者：
KLINGENBERG, M
机构：
[1] Institut für Physikalische Biochemie, Universität München, 8000 München 2
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 03期
关键词：
D O I：
10.1016/0968-0004(90)90194-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The uncoupling protein found in mitochondria from thermogenic brown adipose tissue is structurally very similar to two other mitochondrial carrier proteins transporting ADP/ATP and phosphate, respectively. Similarities are also seen with the mechanism of these carriers, which are part of a family of H+/OH--substrate anion co-transporters, further strengthening the evidence that the uncoupling protein has evolved from this family of mitochondrial carrier proteins. © 1990.
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页码：108 / 112
页数：5
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