SALMONELLA-TYPHIMURIUM GYRA MUTATIONS ASSOCIATED WITH FLUOROQUINOLONE RESISTANCE

被引：67

作者：

REYNA, F ^{[1
]}

HUESCA, M ^{[1
]}

GONZALEZ, V ^{[1
]}

FUCHS, LY ^{[1
]}

机构：

[1] INST NACL SALUD PUBL,CTR INVEST ENFERMEDADES INFECCIOSAS,CUERNAVACA 62508,MORELOS,MEXICO

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 07期

关键词：

D O I：

10.1128/AAC.39.7.1621

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Spontaneous quinolone-resistant mutants obtained from Salmonella typhimurium Su694 were screened for mutations by direct DNA sequencing of an amplified PCR gyrA fragment. Substitutions Ser-83-->Phe (Ser83Phe), Ser83Tyr, Asp87Tyr, and Asp87Asn and double mutation Ala67Pro-Gly81Ser, which resulted in decreased sensitivities to ciprofloxacin, enoxacin, pefloxacin, norfloxacin, ofloxacin, and nalidixic acid, were found. The levels of resistance to quinolones for each mutant were determined.

引用

页码：1621 / 1623

页数：3

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