A NOVEL ADJUVANT FOR USE WITH A BLOOD-STAGE MALARIA VACCINE

被引：14
作者：
DESOUZA, JB
PLAYFAIR, JHL
机构：
来源：
VACCINE | 1995年 / 13卷 / 14期
关键词：
ASEXUAL BLOOD-STAGE; PLASMODIUM YOELII; MALARIA VACCINATION; ADJUVANTS; CYTOKINES;
D O I：
10.1016/0264-410X(95)00025-V
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An effective vaccine delivery system has been developed for vaccination against a blood-stage malaria infection in mice. Subcutaneous vaccination with a semi-purified asexual blood-stage malaria antigen combined with an adjuvant formulation containing squalane, Tween 80 and pluronic L121 (AF) protected mice infected with a lethal P. yoelii infection against death and greatly reduced the severity and duration of parasitaemia. The adjuvant and the route of immunization are both clinically acceptable, thereby making this an attractive delivery system for a human malaria vaccine. Protective immunity appeared to be associated with an enhancement of both Th1 and Th2 subset cytokines.
引用
收藏
页码：1316 / 1319
页数：4
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