REDUCED BIOAVAILABILITY AND EFFECT OF FUROSEMIDE GIVEN WITH FOOD

被引：36

作者：

BEERMANN, B ^{[1
]}

MIDSKOV, C ^{[1
]}

机构：

[1] DUMEX LTD, DEPT BIOL, COPENHAGEN, DENMARK

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1986年 / 29卷 / 06期

关键词：

D O I：

10.1007/BF00615967

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

10 healthy volunteers were given 40 mg furosemide po with and without breakfast. The meal reduced the peak level of furosemide and decreased its bioavailability by approximately 30%. A heavy meal given to 5 of the subjects had no further effect. The reduced bioavailability caused a reduction in the diuretic effect.

引用

页码：725 / 727

页数：3

共 4 条

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BEERMANN, B
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HAMMARLUND, MM
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ODLIND, B
[J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 26 (02) : 197 - 207
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[4] GAS-CHROMATOGRAPHIC DETERMINATION OF FUROSEMIDE IN PLASMA USING AN EXTRACTIVE ALKYLATION TECHNIQUE AND AN ELECTRON-CAPTURE DETECTOR
LINDSTROEM, B
MOLANDER, M
[J]. JOURNAL OF CHROMATOGRAPHY, 1974, 101 (01): : 219 - 221

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