REDUCED BIOAVAILABILITY AND EFFECT OF FUROSEMIDE GIVEN WITH FOOD

被引：36
|
作者：
BEERMANN, B [1 ]
MIDSKOV, C [1 ]
机构：
[1] DUMEX LTD, DEPT BIOL, COPENHAGEN, DENMARK
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1986年 / 29卷 / 06期
关键词：
D O I：
10.1007/BF00615967
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
10 healthy volunteers were given 40 mg furosemide po with and without breakfast. The meal reduced the peak level of furosemide and decreased its bioavailability by approximately 30%. A heavy meal given to 5 of the subjects had no further effect. The reduced bioavailability caused a reduction in the diuretic effect.
引用
收藏
页码：725 / 727
页数：3
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