CORRELATION BETWEEN CHOLINE LEVEL AND GD-DTPA ENHANCEMENT IN PATIENTS WITH BRAIN METASTASES OF MAMMARY-CARCINOMA

被引:42
作者
SIJENS, PE
VANDIJK, P
OUDKERK, M
机构
[1] Dr. Daniel Den Hoed Cancer Center, Ddhcc, Rotterdam, 3008 AE, Groene Hilledijk 301
关键词
BRAIN METASTASES; GD-DTPA CONTRAST AGENT; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY;
D O I
10.1002/mrm.1910320502
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Single voxel H-1 double spin-echo MR spectroscopy was used to examine 15 cases of brain metastasis of mammary carcinoma (18 lesions) in relation to Gd-DTPA enhanced MR imaging. For lesions larger than 50% of MRS voxel size, there was significant correlation between Gd-DTPA-enhanced MRI signal and MRS-detected signal of choline (Cho) containing compounds (r = 0.86, P < 0.01; n = 8). The observed loss of correlation when including the smaller lesions was overcome by correcting for partial volume effects (r = 0.69, P < 0.002; n = 18). Metastasis spectra showed increased Cho compared with control spectra, except for those lesions showing detectable lactate (Lact) signal. The detection of Lact in four of the larger lesions coincided with comparatively low levels of creatine (Cr) and Cho and heterogeneous Gd-DTPA enhancement (ring-enhancement). It was concluded that in brain metastases of mammary carcinoma Lact represents a product of ischemia preceding/during tissue decay resulting in central necrosis, rather than tumor specific metabolism resulting in increased glycolysis.
引用
收藏
页码:549 / 555
页数:7
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