PHOSPHORYLATION AND DNA-BINDING OF THE OCTAMER BINDING TRANSCRIPTION FACTOR OCT-3

被引：4
|
作者：
ROSFJORD, E
SCHOLTZ, B
LEWIS, R
RIZZINO, A
机构：
[1] UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC & ALLIED DIS,OMAHA,NE 68198
[2] UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL,OMAHA,NE 68198
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 212卷 / 03期
关键词：
D O I：
10.1006/bbrc.1995.2046
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phosphorylation influences DNA binding and transactivator capabilities of multiple transcription factors. In this study, we demonstrate that the POU-domain transcription factor, Oct-3, can be phosphorylated in vivo. In addition, we show that in COS-1 cells Oct-3 is phosphorylated exclusively on serine residues. Lastly, we provide evidence that phosphorylation is not required for Oct-3 binding to DNA and treatment of Oct-3 with calf intestinal alkaline phosphatase does not influence its ability to bind DNA. (C) 1995 Academic Press, Inc.
引用
收藏
页码：847 / 853
页数：7
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