EFFECTS OF BIMOLANE AND PROBIMANE ON THE INCORPORATION OF [H-3] TDR, [H-3] UR AND [H-3] LEU INTO EHRLICH ASCITES-CARCINOMA CELLS-INVITRO

被引：0

作者：

WANG, MY ^{[1
]}

LUI, TX ^{[1
]}

LI, GD ^{[1
]}

ZHANG, TM ^{[1
]}

机构：

[1] HENAN MED INST, DEPT PHARMACOL, ZHENGZHOU 450052, PEOPLES R CHINA

来源：

ACTA PHARMACOLOGICA SINICA | 1988年 / 9卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By means of liquid scintillation spectrometry, the effects of bimolane (AT-1727) and probimane (AT-2153) on the incorporation of [3H]TdR, [3H]UR and [3H]Leu into the Ehrlich ascites carcinoma cells were studied. The incorporation of [3H]TdR, [3H]UR and [3H]Leu into ECA cells was quickly inhibited after being exposed to AT-1727 and AT-2153, and the rate of inhibition showed a close relationship to the dosage of the drugs. The inhibition recovered after the removal of AT-1727, but the recovering was slow after the removal of AT-2153. This experiment showed that AT-1727 exerted an inhibitory action on DNA synthesis in tumor cells through interfering the metabolism of DNA while AT-2153 through the damage of DNA template of tumor cells.

引用

页码：367 / 369

页数：3