Applications of immunohistochemistry

被引:141
作者
Duraiyan, Jeyapradha [1 ]
Govindarajan, Rajeshwar [2 ]
Kaliyappan, Karunakaran [2 ]
Palanisamy, Murugesan [3 ]
机构
[1] Thai Moogambigai Dent Coll & Hosp, Dept Oral & Maxillofacial Pathol, Madras, Tamil Nadu, India
[2] JKK Nataraja Dent Coll & Hosp, Dept Oral & Maxillofacial Pathol, Namakkal, Tamil Nadu, India
[3] JKK Nataraja Dent Coll & Hosp, Dept Biochem, Namakkal, Tamil Nadu, India
关键词
Antibody; antigen; disease; immunohistochemistry;
D O I
10.4103/0975-7406.100281
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Immunohistochemistry (IHC) is an important application of monoclonal as well as polyclonal antibodies to determine the tissue distribution of an antigen of interest in health and disease. IHC is widely used for diagnosis of cancers; specific tumor antigens are expressed de novo or up-regulated in certain cancers. This article deals with the various applications of IHC in diagnosis of diseases, with IHC playing an important role in diagnostic and research laboratories.
引用
收藏
页码:S307 / S309
页数:3
相关论文
共 16 条
[1]  
Ajura AJ, 2007, J PATHOL, V29, P101
[2]   Histological examination has a major impact on macroscopic necropsy diagnoses [J].
Bernardi, FDC ;
Saldiva, PHN ;
Mauad, T .
JOURNAL OF CLINICAL PATHOLOGY, 2005, 58 (12) :1261-1264
[3]  
Coons AH, 1941, P SOC EXP BIOL MED, V47, P200, DOI 10.3181/00379727-47-13084P
[4]  
COONS AH, 1950, J EXP MED, V91, P1, DOI 10.1084/jem.91.1.1
[5]  
Edgar MA, 2008, ARCH PATHOL LAB MED, V132, P500, DOI 10.1043/1543-2165(2008)132[500:TDDOCN]2.0.CO
[6]  
2
[7]  
FAULK WP, 1971, IMMUNOCHEMISTRY, V8, P1081
[8]  
Garcia CF, 2009, ARCH PATHOL LAB MED, V133, P756, DOI 10.1043/1543-2165-133.5.756
[9]   THE CONTRIBUTION OF IMMUNOHISTOCHEMICAL STAINING IN TUMOR-DIAGNOSIS [J].
LEONG, ASY ;
WRIGHT, J .
HISTOPATHOLOGY, 1987, 11 (12) :1295-1305
[10]   ALKALINE-PHOSPHATASE AND PEROXIDASE FOR DOUBLE IMMUNOENZYMATIC LABELING OF CELLULAR CONSTITUENTS [J].
MASON, DY ;
SAMMONS, R .
JOURNAL OF CLINICAL PATHOLOGY, 1978, 31 (05) :454-460