CONFORMATIONAL FEATURES OF IMIPRAMINE HYDROCHLORIDE IN AQUEOUS-SOLUTION AS DETECTED BY H-1-NMR RELAXATION ANALYSIS

被引：1

作者：

GAGGELLI, E ^{[1
]}

MARCHETTINI, N ^{[1
]}

VALENSIN, G ^{[1
]}

机构：

[1] UNIV SIENA,DEPT CHEM,PIAN MANTELLINI 44,I-53100 SIENA,ITALY

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1991年 / 29卷 / 09期

关键词：

H-1; NMR; IMIPRAMINE CONFORMATION IN SOLUTION; SELF-ASSOCIATION; DIMERIZATION CONSTANT; MOTIONAL CORRELATION TIMES;

D O I：

10.1002/mrc.1260290912

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Proton NMR measurements were performed and H-1-H-1 dipolar interaction energies were measured to delineate the conformation of imipramine in solution. Self-association of imipramine into dimers was observed and a dimerization constant of 12 l mol-1 was calculated. The motional correlation times for the monomer and the dimer were calculated at tau-cm = 0.18 ns and tau-cd = 0.36 ns, respectively. The geometry of the self-stacked dimer was analysed by measuring intermolecular dipolar cross-relaxation rates and interpreted in terms of the conformation of the aminoalkyl moiety.

引用

页码：933 / 935

页数：3

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