SUBSTITUTED BENZALDEHYDES DESIGNED TO INCREASE THE OXYGEN-AFFINITY OF HUMAN-HEMOGLOBIN AND INHIBIT THE SICKLING OF SICKLE ERYTHROCYTES

被引：108
作者：
BEDDELL, CR
GOODFORD, PJ
KNEEN, G
WHITE, RD
WILKINSON, S
WOOTTON, R
机构：
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1984年 / 82卷 / 02期
关键词：
D O I：
10.1111/j.1476-5381.1984.tb10775.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：397 / 407
页数：11
相关论文
共 24 条
[1]   X-RAY-DIFFRACTION STUDY OF BINDING OF 2,3-DIPHOSPHOGLYCERATE TO HUMAN DEOXYHEMOGLOBIN [J].
ARNONE, A .
NATURE, 1972, 237 (5351) :146-&
[2]   HEMOGLOBIN - STRUCTURAL-CHANGES RELATED TO LIGAND-BINDING AND ITS ALLOSTERIC MECHANISM [J].
BALDWIN, J ;
CHOTHIA, C .
JOURNAL OF MOLECULAR BIOLOGY, 1979, 129 (02) :175-+
[3]   STRUCTURE OF HUMAN CARBONMONOXY HEMOGLOBIN AT 2.7-A RESOLUTION [J].
BALDWIN, JM .
JOURNAL OF MOLECULAR BIOLOGY, 1980, 136 (02) :103-128
[4]   SPECIES-DIFFERENCES IN THE BINDING OF COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN ADULT HUMAN HEMOGLOBIN [J].
BEDDELL, CR ;
GOODFORD, PJ ;
STAMMERS, DK ;
WOOTTON, R .
BRITISH JOURNAL OF PHARMACOLOGY, 1979, 65 (03) :535-543
[5]   COMPOUNDS DESIGNED TO FIT A SITE OF KNOWN STRUCTURE IN HUMAN HEMOGLOBIN [J].
BEDDELL, CR ;
GOODFORD, PJ ;
NORRINGTON, FE ;
WILKINSON, S ;
WOOTTON, R .
BRITISH JOURNAL OF PHARMACOLOGY, 1976, 57 (02) :201-209
[6]  
BEDDELL CR, 1978, BR J PHARMAC, V66, pP70
[7]   EFFECT OF ORGANIC PHOSPHATES FROM HUMAN ERYTHROCYTE ON ALLOSTERIC PROPERTIES OF HEMOGLOBIN [J].
BENESCH, R ;
BENESCH, RE .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1967, 26 (02) :162-&
[8]   PYRIDOXAL COMPOUNDS AS SPECIFIC REAGENTS FOR ALPHA AND BETA N-TERMINI OF HEMOGLOBIN [J].
BENESCH, RE ;
YUNG, S ;
SUZUKI, T ;
BAUER, C ;
BENESCH, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (09) :2595-2599
[9]   COMPUTER-GRAPHICS IN DRUG DESIGN - MOLECULAR MODELING OF THYROID-HORMONE PRE-ALBUMIN INTERACTIONS [J].
BLANEY, JM ;
JORGENSEN, EC ;
CONNOLLY, ML ;
FERRIN, TE ;
LANGRIDGE, R ;
OATLEY, SJ ;
BURRIDGE, JM ;
BLAKE, CCF .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (07) :785-790
[10]   O DIMENSIONAL FOURIER SYNTHESIS OF HORSE DEOXYHAEMOGLOBIN AT 2.8 A RESOLUTION [J].
BOLTON, W ;
PERUTZ, MF .
NATURE, 1970, 228 (5271) :551-&
123