ELEVATED CEREBROSPINAL-FLUID LEVELS OF SUBSTANCE-P IN PATIENTS WITH THE FIBROMYALGIA SYNDROME

被引：469
作者：
RUSSELL, IJ
ORR, MD
LITTMAN, B
VIPRAIO, GA
ALBOUKREK, D
MICHALEK, JE
LOPEZ, Y
MACKILLIP, F
机构：
[1] PFIZER INC, CENT RES, GROTON, CT 06340 USA
[2] ARMSTRONG LAB, BROOKS AFB, TX USA
来源：
ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 11期
关键词：
D O I：
10.1002/art.1780371106
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective. To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients. Methods. CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radioimmunoassay. Clinical measures included tender point examination and standardized questionnaires. Results. CSF SP levels were 3-fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination. Conclusion. SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.
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页码：1593 / 1601
页数：9
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