LOCALIZATION OF MUSCARINIC RECEPTOR SUBTYPES IN BRAIN-STEM AREAS REGULATING SLEEP

被引：44

作者：

BAGHDOYAN, HA

MALLIOS, VJ

DUCKROW, RB

MASH, DC

机构：

[1] UNIV CONNECTICUT,CTR HLTH SCI,DEPT NEUROL,FARMINGTON,CT 06030

[2] UNIV MIAMI,SCH MED,DEPT NEUROL,MIAMI,FL 33101

来源：

NEUROREPORT | 1994年 / 5卷 / 13期

关键词：

RAPID EYE MOVEMENT (REM) SLEEP; DORSAL RAPHE; LOCUS COERULEUS; RETICULAR FORMATION; LATERODORSAL TEGMENTAL NUCLEUS; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; GIGANTOCELLULAR TEGMENTAL HELD; QUANTITATIVE AUTORADIOGRAPHY;

D O I：

10.1097/00001756-199408150-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MUSCARINIC cholinergic receptors (mAChRs) within the pontine brain stem play a key role in generating rapid eye movement (REM) sleep. Using an in vitro autoradiographic technique that permits selective labeling of mAChR subtypes by radioligand binding, this study provides the first quantitative map of mAChR subtypes in cat brain stem areas important for REM sleep generation. M1, M2 and M3 mAChR subtypes were distributed heterogeneously throughout the brain stem. For all 3 mAChR subtypes, the greatest levels of binding were found in the dorsal raphe and locus coeruleus, and the least amount of binding was in the reticular formation. These findings are consistent with data from in vivo studies showing that multiple mAChR subtypes are involved in REM sleep generation.

引用

页码：1631 / 1634

页数：4