ANTIHYPERTENSIVE EFFECTS OF PEPTIDES IN AUTOLYSATE OF BONITO BOWELS ON SPONTANEOUSLY HYPERTENSIVE RATS

被引：17

作者：

FUJII, M ^{[1
]}

MATSUMURA, N ^{[1
]}

MITO, K ^{[1
]}

SHIMIZU, T ^{[1
]}

KUWAHARA, M ^{[1
]}

SUGANO, S ^{[1
]}

KARAKI, H ^{[1
]}

机构：

[1] UNIV TOKYO, FAC AGR, DEPT VET MED SCI, BUNKYO KU, TOKYO 113, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1993年 / 57卷 / 12期

关键词：

D O I：

10.1271/bbb.57.2186

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An autolysate of bonito bowels was treated with ultrafiltration, loose RO concentration, ion-exchange chromatography, and reverse phase chromatography to increase its potency to inhibit angiotensin 1-converting enzyme (ACE) activity by 16-fold. Oral administration of the partially purified autolysate decreased the systolic blood pressure of spontaneously hypertensive rats (SHR) in a dose-dependent manner at the doses of 1 g peptides/kg or higher. The relationship between the antihypertensive activity (in vivo) of the partially purified preparation and its ACE inhibitory activity (in vitro) in comparison with previously reported ACE inhibitory peptides is discussed.

引用

页码：2186 / 2188

页数：3

共 7 条

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