ENHANCED HEPATOTOXICITY OF AFLATOXIN-B1 IN THE RAT BY ETHANOL - ULTRASTRUCTURAL-CHANGES

被引:3
作者
SAHAPHONG, S
TOSKULKAO, C
GLINSUKON, T
机构
[1] MAHIDOL UNIV,FAC SCI,DEPT PHYSIOL,RAMA 6 RD,BANGKOK 10400,THAILAND
[2] MAHIDOL UNIV,FAC SCI,DEPT PATHOBIOL,BANGKOK 10400,THAILAND
关键词
AFLATOXIN-B1; ETHANOL; HEPATOTOXICITY; NECROSIS;
D O I
10.1016/0378-4274(92)90067-T
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The effect of ethanol pretreatment on aflatoxin B1 (AFB1)-induced ultrastructural alteration in hepatocytes was investigated in male Wistar rats. Pretreatment with 4 oral doses of ethanol (4.0 g/kg body wt. each) at 48, 45, 24 and 21 h prior to a single intraperitoneal administration of AFB1 (2.0 mg/kg body wt.) produced an alteration of fine structure more extensive than that observed after administration of AFB1 or ethanol alone. The organelles most affected were the mitochondria, endoplasmic reticulum and nucleus. The degree of nuclear edema, rough endoplasmic reticulum dilatation and mitochondrial swelling in hepatocytes from rats treated with ethanol and AFB1 was much greater than that of hepatocytes from rats treated with AFB1 or ethanol alone. Thus, ethanol may play a specific role in the potentiation of hepatic injury induced by AFB1 at the mitochondrial, endoplasmic reticular and nuclear level.
引用
收藏
页码:89 / 98
页数:10
相关论文
共 15 条
[1]  
Bushby W. F., 1979, FOOD BORNE INFECTION, P519
[2]  
BUTLER WH, 1966, AM J PATHOL, V49, P113
[3]   DIFFERENCES IN AFLATOXIN-B1-SUSCEPTIBILITY OF RAT AND MOUSE ARE CORRELATED WITH THE CAPABILITY INVITRO TO INACTIVATE AFLATOXIN-B1-EPOXIDE [J].
DEGEN, GH ;
NEUMANN, HG .
CARCINOGENESIS, 1981, 2 (04) :299-306
[4]   AFLATOXIN-B1 HEPATOTOXICITY IN RATS PRETREATED WITH ETHANOL [J].
GLINSUKON, T ;
TAYCHARPIPRANAI, S ;
TOSKULKAO, C .
EXPERIENTIA, 1978, 34 (07) :869-870
[5]  
MENDEZ J, 1975, CLIN CHEM, V21, P768
[6]  
MILLER DM, 1980, AM J VET RES, V43, P273
[7]   A COLORIMETRIC METHOD FOR THE DETERMINATION OF SERUM GLUTAMIC OXALACETIC AND GLUTAMIC PYRUVIC TRANSAMINASES [J].
REITMAN, S ;
FRANKEL, S .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1957, 28 (01) :56-63
[8]  
THERON JJ, 1965, LAB INVEST, V14, P1586
[9]   TIME-COURSE EFFECTS OF ETHANOL PRETREATMENT ON HEPATIC-NECROSIS AND FAT ACCUMULATION INDUCED BY AFLATOXIN-B1 IN THE RAT [J].
TOSKULKAO, C ;
LOHAKACHONPAN, P ;
GLINSUKON, T .
TOXICOLOGY LETTERS, 1991, 55 (01) :1-9
[10]   HEPATIC MITOCHONDRIAL-FUNCTION AND LYSOSOMAL-ENZYME ACTIVITY IN ETHANOL-POTENTIATED AFLATOXIN-B1 HEPATOTOXICITY [J].
TOSKULKAO, C ;
GLINSUKON, T .
TOXICOLOGY LETTERS, 1990, 52 (02) :179-190