THE COMPLEX BETWEEN CARBOXYPEPTIDASE-A AND A POSSIBLE TRANSITION-STATE ANALOG - MECHANISTIC INFERENCES FROM HIGH-RESOLUTION X-RAY STRUCTURES OF ENZYME-INHIBITOR COMPLEXES

被引：88

作者：

CHRISTIANSON, DW ^{[1
]}

LIPSCOMB, WN ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM,GIBBS CHEM LABS,CAMBRIDGE,MA 02138

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1986年 / 108卷 / 16期

关键词：

D O I：

10.1021/ja00276a048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：4998 / 5003

页数：6

共 44 条

[1] ON SIZE OF ACTIVE SITE IN PROTEASES .2. CARBOXYPEPTIDASE-A [J].

ABRAMOWITZ, N ;

SCHECHTER, I ;

BERGER, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1967, 29 (06) :862-+

[2] EVOLUTION OF ENZYME FUNCTION AND DEVELOPMENT OF CATALYTIC EFFICIENCY [J].

ALBERY, WJ ;

KNOWLES, JR .

BIOCHEMISTRY, 1976, 15 (25) :5631-5640

[3] H-1-NMR STUDY OF COBALT(II)-SUBSTITUTED CARBOXYPEPTIDASE-A [J].

BERTINI, I ;

CANTI, G ;

LUCHINAT, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (18) :4943-4946

[4]

BOLOGNESI MC, 1979, J BIOL CHEM, V254, P634

[5] STRUCTURE OF THE COMPLEX BETWEEN AN UNEXPECTEDLY HYDROLYZED PHOSPHONAMIDATE INHIBITOR AND CARBOXYPEPTIDASE-A [J].

CHRISTIANSON, DW ;

LIPSCOMB, WN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (03) :545-546

[6] BINDING OF A POSSIBLE TRANSITION-STATE ANALOG TO THE ACTIVE-SITE OF CARBOXYPEPTIDASE-A [J].

CHRISTIANSON, DW ;

LIPSCOMB, WN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :6840-6844

[7] NOVEL STRUCTURE OF THE COMPLEX BETWEEN CARBOXYPEPTIDASE-A AND A KETONIC SUBSTRATE-ANALOG [J].

CHRISTIANSON, DW ;

KUO, LC ;

LIPSCOMB, WN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (26) :8281-8283

[8]

Ferscht A., 1977, ENZYME STRUCTURE MEC

[9] INHIBITION OF CARBOXYPEPTIDASE-A BY ALDEHYDE AND KETONE SUBSTRATE-ANALOGS [J].

GALARDY, RE ;

KORTYLEWICZ, ZP .

BIOCHEMISTRY, 1984, 23 (09) :2083-2087

[10] SITE-DIRECTED MUTAGENESIS SHOWS THAT TYROSINE 248 OF CARBOXYPEPTIDASE-A DOES NOT PLAY A CRUCIAL ROLE IN CATALYSIS [J].

GARDELL, SJ ;

CRAIK, CS ;

HILVERT, D ;

URDEA, MS ;

RUTTER, WJ .

NATURE, 1985, 317 (6037) :551-555

← 1 2 3 4 5 →