A MOUSE MACROPHAGE FACTOR INDUCED HEAD STRUCTURES AND ORGANIZES A BODY AXIS IN XENOPUS

被引：124

作者：

SOKOL, S ^{[1
]}

WONG, GG ^{[1
]}

MELTON, DA ^{[1
]}

机构：

[1] GENET INST,CAMBRIDGE,MA 02140

来源：

SCIENCE | 1990年 / 249卷 / 4968期

关键词：

D O I：

10.1126/science.2382134

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Soluble peptide factors have been implicated as the agents responsible for embryonic inductions in vertebrates. Here, a protein (PIF) secreted by a mouse macrophage cell line is shown to change the developmental fate of Xenopus embryonic cells. Exposure to PIF causes presumptive ectodermal explants to form anterior neural and mesodermal tissues, including brain and eye, instead of ciliated epidermis. In addition, the induced tissues are organized into a rudimentary embryonic axis. These results suggest that PIF or a closely related molecule is involved in inducing anterior structures and organizing the frog body plan.

引用

页码：561 / 564

页数：4

共 33 条

[1] INVOLVEMENT OF THE XENOPUS HOMEOBOX GENE XHOX3 IN PATTERN-FORMATION ALONG THE ANTERIOR POSTERIOR AXIS [J].