T-HELPER CELLS

被引：29

作者：

NOELLE, R ^{[1
]}

SNOW, EC ^{[1
]}

机构：

[1] UNIV KENTUCKY, MED CTR, DEPT MICROBIOL & IMMUNOL, LEXINGTON, KY 40536 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 03期

关键词：

D O I：

10.1016/0952-7915(92)90085-S

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B-cell proliferation and differentiation is controlled by T helper ce s. Recent studies have determined that the expression of a novel, 39kD, T-cell membrane protein is responsible for inducing T-cell-dependent B-cell activation. The receptor for this protein on the resting B cell is CD40. Once activated, B cells are induced to grow and differentiate by the elaboration of interleukin-4 and interleukin-5 from activated T cells. Together, T cell-B cell contact and soluble factors provide all the signals required for B-cell growth and differentiation.

引用

页码：333 / 337

页数：5

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