PALLADIUM-CATALYZED HYDROXYCARBONYLATION OF VINYL AND ARYL TRIFLATES - SYNTHESIS OF ALPHA,BETA-UNSATURATED AND AROMATIC CARBOXYLIC-ACIDS

被引：57

作者：

CACCHI, S ^{[1
]}

LUPI, A ^{[1
]}

机构：

[1] UNIV CATTOLICA SACRO CUORE, FAC MED & CHIRURG A GEMELLI,IST CHIM,CNR, CTR STUDIO, I-00168 ROME, ITALY

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(00)74824-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed hydroxycarbonylation of vinyl and aryl triflates, under a CO balloon, in the presence of potassium acetate affords alpha,beta-unsaturated and aromatic carboxylic acids with one more carbon in good to high yield. The nature of the solvent and of the ligand have been proved to be crucial for the success of the reaction. Vinyl triflates undergo the hydroxycarbonylation at room temperature in DMF in the presence of Pd(OAc)2(PPh3)2. Aryl triflates produce best results at 60-degrees-C in DMSO in the presence of Pd(OAC)2 and 1,1-bis (diphenylphosphino)ferrocene (dppf).

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页码：3939 / 3942

页数：4

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