ACTIONS OF ENDOTHELIN-1 ON PROSTAGLANDIN PRODUCTION BY GESTATIONAL TISSUES

被引：31
|
作者：
MITCHELL, MD [1 ]
ROMERO, RJ [1 ]
LEPERA, R [1 ]
RITTENHOUSE, L [1 ]
EDWIN, SS [1 ]
机构：
[1] YALE UNIV,DEPT OBSTET & GYNECOL,NEW HAVEN,CT 06520
来源：
PROSTAGLANDINS | 1990年 / 40卷 / 06期
关键词：
D O I：
10.1016/0090-6980(90)90007-I
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endothelin-1 (10(-11)M-10(-7)M) was incubated with human umbilical vein endothelial cells and cells derived from amnion and decidua and prostaglandin production was determined. The rates of biosynthesis of 6-keto-prostaglandin F1-alpha (6-keto-PGF1-alpha) and prostaglandin E2 (PGE2) by endothelial cells were increased significantly by treatment with endothelin-1. Amnion cell PGE2 production was reduced significantly by endothelin-1 treatment whereas decidual PGE2 and prostaglandin F2-alpha production was unaffected by this treatment. Thus, it is possible that endothelins may play a part in the regulation of uteroplacental hemodynamics and the mechanisms of parturition.
引用
收藏
页码：627 / 635
页数：9
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