FAMILIAL AGGREGATION IN TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS - A STUDY FROM SOUTH-INDIA

被引：9

作者：

RAMACHANDRAN, A

SNEHALATHA, C

PREMILA, L

MOHAN, V

VISWANATHAN, M

机构：

[1] Diabetes Research Centre, M. V. Hospital for Diabetes, Madras, Royapuram

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 10期

关键词：

Familial aggregation; Family history of diabetes; Risk of diabetes India; Type 1 (insulin‐dependent) diabetes;

D O I：

10.1111/j.1464-5491.1990.tb01322.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An analysis of 617 Type 1 (insulin‐dependent) diabetic patients from 587 families was made. In 33 families (5.6%) there was more than one Type 1 diabetic patient. In 98 families (16.7%) positive family history of Type 2 (non‐insulin‐dependent) diabetes was present. There was a linear correlation between the age at diagnosis of the proband and that of the sibling (r = 0.73, p < 0.001) in the Type 1 multiplex families. The risk of Type 1 diabetes in relatives was found to be 2.7% by Li Mantel estimate, which is lower than that reported among Europeans. The cumulative risk was higher (p < 0.001) in the relatives of Type 1 diabetic patients with age at diagnosis 10 years. 1990 Diabetes UK

引用

页码：876 / 879

页数：4

共 10 条

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