DNA AND PROTEIN-SYNTHESIS IN NORMAL AND TRANSFORMED LYMPHOCYTES EXPOSED TO ABRIN

被引：3
作者：
BENNETT, CE
GLASSMAN, AB
WITTEN, M
机构：
[1] UNIV CALIF SANTA BARBARA, DEPT MATH, SANTA BARBARA, CA 93106 USA
[2] MED UNIV S CAROLINA, DEPT LAB MED, CHARLESTON, SC 29403 USA
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1982年 / 16卷 / 01期
关键词：
D O I：
10.1016/0091-3057(82)90034-X
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The dose dependent effects of [the antineoplastic drug] abrin, a toxic D-galactose binding plant lectin, on 3H-TdR [thymidine] and 14C-Leu uptake were studied in normal and Epstein-Barr virus (EBV)-transformed [human] lymphocyte cultures. While abrin was highly toxic to the DNA and protein synthesis in EBV lymphocytes, some toxicity to the normal cells was also seen. Lymphocyte DNA synthesis was possibly affected by ribosomal shutdown induced by the abrin.
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页码：185 / 188
页数：4
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