DEVELOPMENT AND APPLICATION OF A CONTINUOUS MICROWAVE REACTOR FOR ORGANIC-SYNTHESIS

被引：218

作者：

CABLEWSKI, T ^{[1
]}

FAUX, AF ^{[1
]}

STRAUSS, CR ^{[1
]}

机构：

[1] CSIRO,DIV CHEM & POLYMERS,CLAYTON,VIC 3169,AUSTRALIA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 12期

关键词：

D O I：

10.1021/jo00091a033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A laboratory-scale continuous microwave reactor (CMR) has been developed and used to conduct organic syntheses routinely, rapidly, and safely in a range of solvents, under pressures up to 1400 kPa and at temperatures up to 200 degrees C. Advantages and applications of the CMR are discussed, along with the rationale for the design. Reactions carried out with the CMR included nucleophilic substitution, addition, esterification, transesterification, acetalization, amidation, base- and acid-catalyzed hydrolysis, isomerization, decarboxylation, and elimination. Name reactions included the Michael addition, Hofmann degradation, Williamson ether synthesis, and the Mannich, Finkelstein, Baylis-Hillman, and Knoevenagel reactions.

引用

页码：3408 / 3412

页数：5

共 31 条

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Abramovich R. A, 1991, ORG PREP P INT, V23, P683

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