A GROWTH ARREST-SPECIFIC (GAS) GENE CODES FOR A MEMBRANE-PROTEIN

被引：238

作者：

MANFIOLETTI, G

RUARO, ME

DELSAL, G

PHILIPSON, L

SCHNEIDER, C

机构：

[1] INT CTR GENET ENGN & BIOTECHNOL, I-34012 TRIESTE, ITALY

[2] EUROPEAN MOLEC BIOL LAB, W-6900 HEIDELBERG, GERMANY

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 06期

关键词：

D O I：

10.1128/MCB.10.6.2924

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A set of growth arrest-specific (gas) genes whose expression is negatively regulated by serum has recently been identified. We report on the detailed analysis of one of these genes (gas3). The kinetics of regulation by the presence and absence of serum were investigated, and it was found that this gene is regulated at the posttranscriptional level. The encoded protein deduced from the nucleotide sequence showed some similarity to a mitochondrial oxyreductase, and in vitro translation established that the protein product is a transmembrane glycoprotein.

引用

页码：2924 / 2930

页数：7

共 28 条

[1] EXPRESSION, CLONING AND CDNA SEQUENCE OF A FIBROBLAST SERUM-REGULATED GENE ENCODING A PUTATIVE ACTIN-ASSOCIATED PROTEIN (P27) [J].