DECREASED HIPPOCAMPAL EXPRESSION OF A GLUTAMATE RECEPTOR GENE IN SCHIZOPHRENIA

被引：214

作者：

HARRISON, PJ

MCLAUGHLIN, D

KERWIN, RW

机构：

[1] INST PSYCHIAT,DEPT NEUROSCI,DE CRESPIGNY PK,LONDON SE5 8AF,ENGLAND

[2] INST PSYCHIAT,DEPT PSYCHIAT,LONDON SE5 8AF,ENGLAND

[3] ST MARYS HOSP,SCH MED,DEPT ANAT,LONDON W2 1PG,ENGLAND

[4] ST MARYS HOSP,SCH MED,DEPT PSYCHIAT,LONDON W2 1PG,ENGLAND

来源：

LANCET | 1991年 / 337卷 / 8739期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0140-6736(91)93392-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A striking and specific loss of the messenger RNA that encodes a non-N-methyl D-aspartate (non-NMDA) glutamate receptor was found in hippocampal tissue obtained at necropsy from 6 patients with schizophrenia, when compared to specimens from 8 controls without neurological or psychiatric signs or symptoms. These findings support suggestions of aberrant glutamatergic function in schizophrenia. Evidence that gene expression may be abnormal in schizophrenia, with decreased production of an excitatory neurotransmitter receptor, may have therapeutic as well as pathogenetic implications.

引用

页码：450 / 452

页数：3

共 25 条

[1]

ALTSHULER LL, 1987, ARCH GEN PSYCHIAT, V44, P1094

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