USE OF PHYSICOCHEMICAL PARAMETERS IN DISTANCE GEOMETRY AND RELATED 3-DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS - A DEMONSTRATION USING ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE INHIBITORS

被引：66
作者：
GHOSE, AK [1 ]
CRIPPEN, GM [1 ]
机构：
[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 03期
关键词：
D O I：
10.1021/jm00381a013
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：333 / 346
页数：14
相关论文
共 29 条
[1]   DIFFERENTIAL BINDING TO HYDROPHOBIC BONDING REGION OF T2 PHAGE INDUCED ESCHERICHIA COLI B AND PIGEON LIVER DIHYDROFOLIC REDUCTASES [J].
BAKER, BR .
JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (05) :912-&
[2]   THE BINDING OF TRIMETHOPRIM TO BACTERIAL DIHYDROFOLATE-REDUCTASE [J].
BAKER, DJ ;
BEDDELL, CR ;
CHAMPNESS, JN ;
GOODFORD, PJ ;
NORRINGTON, FEA ;
SMITH, DR ;
STAMMERS, DK .
FEBS LETTERS, 1981, 126 (01) :49-52
[3]   TRIMETHOPRIM BINDING TO BACTERIAL AND MAMMALIAN DIHYDROFOLATE-REDUCTASE - A COMPARISON BY PROTON AND C-13 NUCLEAR MAGNETIC-RESONANCE [J].
BIRDSALL, B ;
ROBERTS, GCK ;
FEENEY, J ;
DANN, JG ;
BURGEN, ASV .
BIOCHEMISTRY, 1983, 22 (24) :5597-5604
[4]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[5]  
BROTO P, 1984, EUR J MED CHEM, V19, P71
[6]   DISTANCE GEOMETRY APPROACH TO RATIONALIZING BINDING DATA [J].
CRIPPEN, GM .
JOURNAL OF MEDICINAL CHEMISTRY, 1979, 22 (08) :988-997
[7]  
FILMAN DJ, 1982, J BIOL CHEM, V257, P13663
[8]   GENERAL DISTANCE GEOMETRY 3-DIMENSIONAL RECEPTOR MODEL FOR DIVERSE DIHYDROFOLATE-REDUCTASE INHIBITORS [J].
GHOSE, AK ;
CRIPPEN, GM .
JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (07) :901-914
[9]   COMBINED DISTANCE GEOMETRY ANALYSIS OF DIHYDROFOLATE-REDUCTASE INHIBITION BY QUINAZOLINES AND TRIAZINES [J].
GHOSE, AK ;
CRIPPEN, GM .
JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (07) :996-1010
[10]   QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP BY DISTANCE GEOMETRY - QUINAZOLINES AS DIHYDROFOLATE-REDUCTASE INHIBITORS [J].
GHOSE, AK ;
CRIPPEN, GM .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) :892-899
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