USE OF PHYSICOCHEMICAL PARAMETERS IN DISTANCE GEOMETRY AND RELATED 3-DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS - A DEMONSTRATION USING ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE INHIBITORS

被引：66

作者：

GHOSE, AK ^{[1
]}

CRIPPEN, GM ^{[1
]}

机构：

[1] TEXAS A&M UNIV,DEPT CHEM,COLLEGE STN,TX 77843

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 03期

关键词：

D O I：

10.1021/jm00381a013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：333 / 346

页数：14

共 30 条

[1] QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS BY DISTANCE GEOMETRY - SYSTEMATIC ANALYSIS OF DIHYDROFOLATE-REDUCTASE INHIBITORS
CRIPPEN, GM
JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (06) : 599 - 606
[2] QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP BY DISTANCE GEOMETRY - QUINAZOLINES AS DIHYDROFOLATE-REDUCTASE INHIBITORS
GHOSE, AK
CRIPPEN, GM
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (08) : 892 - 899
[3] GENERAL DISTANCE GEOMETRY 3-DIMENSIONAL RECEPTOR MODEL FOR DIVERSE DIHYDROFOLATE-REDUCTASE INHIBITORS
GHOSE, AK
CRIPPEN, GM
JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (07) : 901 - 914
[4] QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF DIHYDROFOLATE-REDUCTASE INHIBITORS BY NEURAL NETWORKS
HIRST, JD
STERNBERG, MJE
PROTEIN ENGINEERING, 1993, 6 : 107 - 107
[5] QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS FOR THE INHIBITION OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE BY 5-(SUBSTITUTED BENZYL)-2,4-DIAMINOPYRIMIDINES
LI, RL
POE, M
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (02) : 366 - 370
[6] APPLICATIONS OF NEURAL NETWORKS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS OF DIHYDROFOLATE-REDUCTASE INHIBITORS
ANDREA, TA
KALAYEH, H
JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (09) : 2824 - 2836
[7] 3-DIMENSIONAL STRUCTURE OF ESCHERICHIA-COLI DIHYDRODIPICOLINATE REDUCTASE
SCAPIN, G
BLANCHARD, JS
SACCHETTINI, JC
BIOCHEMISTRY, 1995, 34 (11) : 3502 - 3512
[8] CIRCULARLY PERMUTED DIHYDROFOLATE-REDUCTASE OF ESCHERICHIA-COLI HAS FUNCTIONAL-ACTIVITY AND A DESTABILIZED TERTIARY STRUCTURE
PROTASOVA, NY
KIREEVA, ML
MURZINA, NV
MURZIN, AG
UVERSKY, VN
GRYAZNOVA, OI
GUDKOV, AT
PROTEIN ENGINEERING, 1994, 7 (11): : 1373 - 1377
[9] Three-dimensional quantitative structure-activity and structure-selectivity relationships of dihydrofolate reductase inhibitors
Sutherland, JJ
Weaver, DF
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2004, 18 (05) : 309 - 331
[10] Three-dimensional quantitative structure-activity and structure-selectivity relationships of dihydrofolate reductase inhibitors
Jeffrey J. Sutherland
Donald F. Weaver
Journal of Computer-Aided Molecular Design, 2004, 18 : 309 - 331

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