DISSOCIATION OF THE LOCOMOTOR AND HYPOTENSIVE EFFECTS OF ADENOSINE-ANALOGS IN THE RAT

被引：42

作者：

BARRACO, RA ^{[1
]}

AGGARWAL, AK ^{[1
]}

PHILLIS, JW ^{[1
]}

MORON, MA ^{[1
]}

WU, PH ^{[1
]}

机构：

[1] WAYNE STATE UNIV, SCH MED, DEPT PHYSIOL, DETROIT, MI 48201 USA

来源：

NEUROSCIENCE LETTERS | 1984年 / 48卷 / 02期

关键词：

D O I：

10.1016/0304-3940(84)90009-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats implanted with chronic indwelling cannulae were injected in the lateral cerebral ventricle with 2 adenosine analogs with the effects on spontaneous locomotor activity and blood pressure were recorded. Both analogs produced dose-related decreases in locomotor activity, with 5''-N-ethylcarboxamidoadenosine (NECA) exhibiting slightly more potent depressant activity than (-)-N-(1-methyl-2-phenylethyl)adenosine (L-phenylisopropyladenosine) (L-PIA). NECA and L-PIA also produced dose-related reductions in blood pressure, but the threshold dose for hypotensive activity was 10- to 100-fold higher than the dose required for depression of spontaneous locomotor activity. The depression of locomotor activity and the hypotensive effect of both analogs were antagonized by parenteral injections of caffeine. The hypoactive and hypotensive effects of adenosine analogs can be dissociated and methylxanthines probably exert an antagonism of central adenosine receptors in the rat.

引用

页码：139 / 144

页数：6

共 21 条

[1] CENTRAL EFFECTS OF ADENOSINE-ANALOGS ON LOCOMOTOR-ACTIVITY IN MICE AND ANTAGONISM OF CAFFEINE [J].

BARRACO, RA ;

COFFIN, VL ;

ALTMAN, HJ ;

PHILLIS, JW .

BRAIN RESEARCH, 1983, 272 (02) :392-395

[2]

BURNSTOCK G, 1980, CIRC RES, V46, pI175

[3]

COFFIN VL, 1983, PHYSL PHARM ADENOSIN, P267

[4]

COHEN DM, 1983, FED PROC, V42, P1261

[5] BEHAVIORAL CHARACTERIZATION OF 2 LONG-LASTING ADENOSINE-ANALOGS - SEDATIVE PROPERTIES AND INTERACTION WITH DIAZEPAM [J].

CRAWLEY, JN ;

PATEL, J ;

MARANGOS, PJ .

LIFE SCIENCES, 1981, 29 (25) :2623-2630

[6] ADENOSINE RECEPTORS - TARGETS FOR FUTURE DRUGS [J].

DALY, JW .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) :197-207

[7]

DALY JW, 1979, PHYSL REGULATORY FUN, P229

[8]

DUNWIDDIE TV, 1982, J PHARMACOL EXP THER, V220, P70

[9] ADENOSINE RECEPTORS MEDIATING CARDIAC DEPRESSION [J].

EVANS, DB ;

SCHENDEN, JA ;

BRISTOL, JA .

LIFE SCIENCES, 1982, 31 (22) :2425-2432

[10] MODULATION OF NEUROTRANSMISSION BY PURINE NUCLEOTIDES AND NUCLEOSIDES [J].

FREDHOLM, BB ;

HEDQVIST, P .

BIOCHEMICAL PHARMACOLOGY, 1980, 29 (12) :1635-1643

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