Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models

被引：340

作者：

Zhang, X-Y ^{[1
]}

Trame, M. N. ^{[1
]}

Lesko, L. J. ^{[1
]}

Schmidt, S. ^{[1
]}

机构：

[1] Univ Florida, Coll Pharm, Ctr Pharmacometr & Syst Pharmacol, Dept Pharmaceut, Orlando, FL 32827 USA

来源：

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY | 2015年 / 4卷 / 02期

关键词：

D O I：

10.1002/psp4.6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A systems pharmacology model typically integrates pharmacokinetic, biochemical network, and systems biology concepts into a unifying approach. It typically consists of a large number of parameters and reaction species that are interlinked based upon the underlying (patho) physiology and the mechanism of drug action. The more complex these models are, the greater the challenge of reliably identifying and estimating respective model parameters. Global sensitivity analysis provides an innovative tool that can meet this challenge.

引用

页码：69 / 79

页数：11

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