LESION OF THE SUBTHALAMIC NUCLEUS FOR THE ALLEVIATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-INDUCED PARKINSONISM IN THE PRIMATE

被引：422

作者：

AZIZ, TZ ^{[1
]}

PEGGS, D ^{[1
]}

SAMBROOK, MA ^{[1
]}

CROSSMAN, AR ^{[1
]}

机构：

[1] UNIV MANCHESTER,SCH MED,DEPT CELL & STRUCT BIOL,EXPTL NEUROL & MYOL GRP,OXFORD RD,MANCHESTER M13 9PT,LANCS,ENGLAND

来源：

MOVEMENT DISORDERS | 1991年 / 6卷 / 04期

关键词：

SUBTHALAMIC NUCLEUS; MPTP-INDUCED PARKINSONISM; RADIOFREQUENCY LESION;

D O I：

10.1002/mds.870060404

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

引用

页码：288 / 292

页数：5

共 26 条

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