RAPID AND SIMPLE METHOD FOR THE DETERMINATION OF NIMUSTINE HYDROCHLORIDE IN HUMAN BLOOD AND BRAIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：3
|
作者：
TATSUHARA, T [1 ]
TABUCHI, F [1 ]
YAMANE, M [1 ]
HORI, T [1 ]
机构：
[1] TOTTORI UNIV,SCH MED,DEPT NEUROSURG,YONAGO,TOTTORI 683,JAPAN
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1990年 / 526卷 / 02期
关键词：
D O I：
10.1016/S0378-4347(00)82532-3
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple method for the determination of nimustine hydrochloride in blood and brain by high-performance liquid chromatography was developed. A pH 4.52 buffer was used in the extraction from blood and a pH 5.0 buffer was used for brain. A pre-packed Extrelut column was used to make the extraction procedure uncomplicated. At room temperature light-resistant test-tubes were unnecessary. The lower limit of detection was 50 ng/ml for blood and 100 ng/g for brain. This method may be useful for the determination of nimustine hydrochloride in blood and brain samples from patients. © 1990.
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页码：507 / 514
页数：8
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